U.S. Pharmacist Continuing Education
ACPE Program No. 430-000-99-004-H01
This program provides 2.0 hours of credit (0.2 CEU).
Lesson Expires: end of April 2001

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Instructions:

This is a free CE lesson courtesy of Wyeth-Ayerst Laboratories. After reading the lesson, complete all of the information and questions that follow. Social Security number is required for certification. Print a copy of the completed form for your records, and submit for grading. Pharmacists receiving a score of 70% or better will be able to immediately print their certificates. Those who fail may retake it only once.

U.S. Pharmacist  Continuing Education is approved in all states where mandatory continuing education is required. This article has been accredited for two Continuing Education Hours (0.2 CEUs) for each examination successfully completed.

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Questions

1. The predominant estrogen in premenopausal women is:
(A) Estrone
(B) Estriol
(C) Estradiol
(D) Androstenedione

2. The predominant estrogen in postmenopausal women is:
(A) Estrone
(B) Estriol
(C) Estradiol
(D) Androstenedione

3. The central effects of estrogens may be due in part to the formation of:
(A) Catecholestrogens
(B) Dopamine
(C) Serotonin
(D) Both B and C

4. Moderate to high expression of estrogen receptor-beta can be found in: (A) Prostate
(B) Kidney
(C) Brain
(D) Both A and C

5. Estrogen replacement therapy may improve cognitive function through: (A) An abundance of estrogen receptor-alpha
(B) An abundance of estrogen receptor-beta
(C) Both A and B
(D) None of the above

6. Estrogen deficiency can lead to:
(A) Hot flashes
(B) Osteoporosis
(C) Atherosclerosis
(D) All of the above

7. Which of the following is a generic equivalent for CEE? (A) Ogen
(B) Estinyl
(C) Both A and B
(D) None of the above

8. CEE contains how many biologically active conjugated estrogens?
(A) 4
(B) 6
(C) 8
(D) >10

9. Which of the following estrogen components help prevent cardiovascular disease?
(A) Equilin
(B) Equilinen
(C) Estrone
(D) All of the above

10. Which of the following statements apply to marketed generic drugs?
(A) They have the same active ingredient as brand
(B) They have demonstrated bioequivalence to brand
(C) Both A and B
(D) None of the above

11. Which of the following statements regarding the approval of generic conjugated estrogens is true?
(A) ANDAs for synthetic conjugated estrogens have been approved
(B) Generic conjugated estrogens are bioequivalent to brand
(C) All of the active ingredients found in conjugated equine estrogens must be characterized before generics can be approved
(D) None of the above

12. Oral and transdermal estrogen products have different effects on which of the following?
(A) Cardiovascular parameters
(B) Cognitive function
(C) Bone preservation
(D) All of the above

13. The fact that receptor binding affinity does not reflect biological activity is best exemplified by which of the following components?
(A) Estradiol
(B) Estrone
(C) Delta8,9-dehydroestrone
(D) Estriol

14. Which of the following are accurate regarding the paradoxical behavior of estrogens?
(A) Tamoxifen has a role as either an estrogen agonist or an antagonist
(B) A second estrogen receptor was discovered
(C) The individual components of CEE show distinct differences in estrogen action
(D) All of the above

15. In reference to the new information on estrogen receptor biology, which of the following statements is false?
(A) The individual components of CEE may bind to the two estrogen receptors in a discriminating fashion
(B) The special effects of estrogen are based solely on the presence of one estrogen receptor
(C) The two estrogen receptors are expressed differently in different tissues
(D) The action of estrogen on nonreproductive tissues was difficult to explain until a second estrogen receptor was discovered

16. When the same hormone elicits a differential response in various tissues because the tissues have a different receptor composition, this is known as:
(A) Ligand-based selectivity
(B) Receptor-based selectivity
(C) Effector site-based selectivity
(D) None of the above

17. Estrogens are not available as which of the following routes of administration? (A) Transdermal patch
(B) Vaginal cream
(C) Vaginal ring
(D) Rectal suppository

18. Which of the following statements concerning synthetic estrogens is false?
(A) They are most commonly used for oral contraception
(B) They have the most potent hepatic effects
(C) They are traditionally considered the first choice for postmenopausal estrogen therapy
(D) They are associated with blood pressure and clotting problems

19. Endogenous estrogens are known to beneficially affect: (A) Lipid metabolism
(B) Neuronal function
(C) Cardiovascular system
(D) All of the above

20. Which oral estrogen replacement product has consistently been the most widely used in the United States?
(A) CEE
(B) Ethinyl estradiol
(C) Estratest
(D) Estraderm

Before submitting your Exam, it is recommended that you print a copy for your records!

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