S Pharm. 2014;38(3):HS-16.
Researchers from Case Western Reserve University have found how small fatty acids from two bacteria in gum disease, Porphyromonas gingivalis and Fusobacterium nucleatum, promote the growth of Kaposi’s sarcoma (KS) related lesions and tumors in the mouth. The discovery, published in the Journal of Virology, may enable saliva testing for the bacteria, which could be treated and monitored for signs of cancer.
“These new findings provide one of the
first looks at how the periodontal bacteria create a unique
microenvironment in the oral cavity that contributes to the replication
the Kaposi’s sarcoma Herpesvirus (KSHV) and development of KS,” said
Fengchun Ye, the study’s lead investigator from the department of
biological sciences at Case Western’s School of Dental Medicine.
“The most important thing to come out of
this study is that we believe periodontal disease is a risk factor for
Kaposi sarcoma tumor in HIV patients,” Ye said.