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Issue:  June 2011 •  Archive  •  Subscribe •  Unsubscribe
In This Edition Featured Article Featured CE
•  Editor's Notebook
•  Counseling Pearls
•  It's the Law
•  Clinical Corner
•  Consult Your Pharmacist
•  Educational Spotlight
•  Quick Poll
   - Cigarette Warning Label
  Photo Update on the Treatment of Acute Uncomplicated Cystitis and Pyelonephritis in Women
Antimicrobial therapy recommendations for these conditions were revised in 2010.
  Photo Dialysis Concepts: A Review for Clinical Pharmacists
Renal replacement therapy affects the activity and dosing of many drugs.

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Editor's Notebook
The War Against Retail Pharmacy

Pharmacist consultation on patient compliance and adherence is our future and must be embraced.
Counseling Pearls
Photo Benign Prostatic Hyperplasia and the Medication Management of Associated Lower Urinary Tract Symptoms

Serious complications can occur if this common benign tumor goes untreated. Treatment should focus on improving symptoms while limiting side effects from the drugs.
Photo UTIs in the Geriatric Population: Challenges for Clinicians

This condition occurs in diverse segments of the elderly population. Diagnosis and treatment differ based on whether the patient is healthy, chronically ill, or institutionalized.
It's the Law
New FDA Strategy: Criminal Charges Against Pharma Executives

Should pharmaceutical company CEOs be held accountable for off-label promotion of their products?
Clinical Corner
Photo Bladder Cancer: A Review

Its high recurrence rate and propensity to progress render this disease the most expensive of all cancers. Long-term follow-up and treatment are necessary.
Photo Fanconi Syndrome

Limited information about this disorder's pathophysiology makes diagnosis and treatment a challenge. Therapeutic advances are necessary in order to refine current practice.
Consult Your Pharmacist
Prostate and Kidney Precautions With Nonprescription Products

Certain categories of OTC products are problematic for patients with renal or prostate disorders.
Educational Spotlight
Treatment Options in Managing Chronic Low Back Pain

Therapy should be individualized based on the severity of pain and duration of symptoms.
An Overview of Uveitis and Its Management

Significant vision loss can occur in more than one-third of patients with this condition.

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ACS Reports on Cancer Mortality
Atlanta, GA — Current statistics from the American Cancer Society (ACS) reveal that a steady reduction in overall cancer death rates occurred between 1990 and 2007, translating to avoidance of approximately 898,000 cancer-related deaths. Progress has not equally benefited all segments of the population, however. The ACS report Cancer Statistics 2011 and its companion publication, Cancer Facts & Figures 2011, stated that cancer death rates for individuals with the least education are more than twice those of individuals with the most education and that closing the gap could have prevented 37% of premature cancer deaths occurring in people aged 25 to 64 years in 2007. Overall, "The nearly 900,000 cancer deaths avoided over a 17-year period stand in stark contrast to the repeated claim that cancer death rates have not budged," commented John Seffrin, PhD, chief executive officer of the ACS and its advocacy affiliate, the ACS Cancer Action Network.
Intensive Statin Therapy Confers Increased Risk of Diabetes
Glasgow, UKA recent meta-analysis conducted at the University of Glasgow suggests that intensive-dose (ID) statin therapy is associated with a greater risk of new-onset diabetes compared with moderate-dose (MD) therapy. The meta-analysis, which included published and unpublished data from five relevant clinical trials, involved 32,752 subjects without diabetes (roughly half receiving ID therapy and the rest receiving MD therapy) followed for a mean of nearly 5 years. During follow-up, 8.4% of subjects developed diabetes. There were 149 more cases of incident diabetes in ID subjects than in MD subjects. The investigators concluded that clinicians "should be vigilant for the development of diabetes in patients receiving intensive statin therapy."
Vitamin D Stimulates Immune Response in Gum Cells
Newark, NJ—Vitamin D may help protect the gums against bacterial infections that lead to gingivitis and periodontitis. At the University of Medicine and Dentistry of New Jersey, laboratory-grown gingival cells treated with vitamin D increased their production of an endogenous antibiotic protein (LL-37) and killed more bacteria than untreated cells. In addition to LL-37, vitamin D also stimulated gingival cells to produce another protein, TREM-1, which boosts production of proinflammatory cytokines. It was found that vitamin D coordinates expression of a number of genes not previously considered part of the vitamin D pathway. Gum cells appear to be able to activate inactive forms of vitamin D, which may lead to topical therapy.
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