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Issue:  January 2014 •  Archive  •  Subscribe •  Unsubscribe
In This Edition Featured Article Featured CE
•  Editor's Notebook
•  Counseling Pearls
•  TechRx
•  Clinical Corner
•  Consult Your Pharmacist
•  Educational Spotlight
•  Quick Poll
    – Flu Season
  Photo Guillain-BarreĢ Syndrome
This heterogeneous condition is the most common cause of acute flaccid paralysis.
  Photo Current Pharmacologic and Complementary Therapies for Tourette Syndrome
This neurologic disorder is characterized by uncontrolled motor and vocal tics.

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Editor's Notebook
Policing Pharmacy

Is this just the beginning of the FDA policing all licensed pharmacies, a role that has traditionally been the domain of the state Boards of Pharmacy?
Counseling Pearls
Photo Antiepileptic Drugs and Contraception

Certain antiepileptic drugs (AEDs) can interact with hormonal contraceptives and decrease their effectiveness, leading to unplanned pregnancy. In addition, hormonal contraception can have a bidirectional interaction with some AEDs, which can result in loss of seizure control or toxicity.
Photo Adult ADHD: Treatment of a Grown-up Disorder

Attention-deficit/hyperactivity disorder (ADHD) is often thought of as a disorder of childhood, but approximately one-half of individuals who exhibit ADHD early in life will go on to have persistent symptoms into adulthood. These symptoms generally differ in presentation from the typical presentation of a school-aged child with hyperactivity and academic difficulties.
Opportunities for Health Information Technology in Clinical Neurology

Health information technology is impacting clinical neurology in the areas of stroke treatment and home monitoring of patients using blood thinners; it also offers exciting potential in the management of patients with epilepsy.
Clinical Corner
Photo Reversal of Newer Anticoagulants in Acute Hemorrhagic Stroke

With the introduction of the oral direct thrombin inhibitor dabigatran and the factor Xa inhibitors rivaroxaban and apixaban come questions about emergent reversal in the presence of hemorrhagic stroke. There are no currently available antidotes to any of the newer oral anticoagulants.
Photo Tardive Dyskinesia: A Distressing Drug-Induced Movement Disorder

Tardive dyskinesia, a drug-induced movement disorder, is a serious side effect resulting primarily from the prolonged use of dopamine-blocking agents. Most therapies have not proven to be successful, and therefore the best treatment option is prevention of the disorder.
Consult Your Pharmacist
Understanding and Relieving Restless Legs Syndrome

Patients with this movement disorder feel an urgent need to move their legs to stop unpleasant sensations. Three medications have been approved by the FDA for treatment of this condition.
Educational Spotlight
The Clinical Management of Gastroesophageal Reflux Disease

Lifestyle modifications and pharmacotherapy are important components of GERD management.
Issues and Data Associated With Addictive Disease in Pharmacists

Pharmacies can present a precarious environment for the development of addiction.
Drug Rescheduling and Controlled Substances

Federal and state lists of controlled substances and dispensing restrictions continue to evolve.
Prescribing of High-Dose Acetaminophen Products Discouraged
Silver Spring, MD — The FDA has recommended that healthcare professionals discontinue prescribing and dispensing prescription combination drug products that contain more than 325 mg of acetaminophen per tablet, capsule, or other dosage unit. There are no available data to show that taking more than 325 mg of acetaminophen per dosage unit provides additional benefit that outweighs the added risks for liver injury. In addition, limiting the amount of acetaminophen will reduce the risk of severe liver injury from inadvertent overdose, which can lead to liver failure, liver transplantation, and even death. Patients may be unaware that many prescription and OTC products contain acetaminophen, making it easy to accidentally overdose.
Alzheimer's Drug Trials Yield Disappointing Results
Waltham, MA— In separate clinical trials, two experimental drugs for Alzheimer's disease have proven ineffective for patients with mild-to-moderate dementia. According to studies published in the New England Journal of Medicine, neither bapineuzumab nor solanezumab improved patients' ability to think and solve problems or conduct activities of daily living. The drugs were intended to help patients with Alzheimer's disease by clearing the amyloid beta protein plaques that accumulate in their brains. Further research is needed to evaluate whether these types of medications might be useful for earlier disease intervention or prevention.
Drug Holidays for Bisphosphonates Reevaluated
Chicago, IL— New research from the Loyola University Health System amends the recommendations regarding drug holidays for treatment of osteoporosis with bisphosphonates. While the American Association of Clinical Endocrinologists recommends a break from the use of bisphosphonates after about 5 years of bone density stability if osteoporosis is moderate and after 10 years if fracture risk is high, findings recently published in the journal Endocrine Practice show that patients should resume treatment if they develop a fracture, have a decline in bone strength, or have an early rise in signs indicative of increased fracture risk. Researchers also discovered that elderly patients and those with very low bone strength should be closely followed during a break from bisphosphonate therapy.
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