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The Pleiotropic Effects of Statins: A Panacea? 10/17/2008

Landmark clinical trials such as the Scandinavian Simvastatin Survival Study (also known as 4S), the West of Scotland Coronary Prevention Study, the Long-Term Intervention with Pravastatin in Ischemic Disease Trial, the Heart Protection Study, and the Cholesterol and Recurrent Events Trial have solidified the utility of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitors, or statins, for primary and secondary prevention of cardiovascular disease.

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Drug Combination Slows Prostate Cancer Growth 7/18/2008

Attendees at a meeting of the American Association for Cancer Research learned that while the results of a study conducted at Rutgers University in New Brunswick, NJ, showed that atorva­ statin (Lipitor) and celecoxib (Celebrex) individually slowed tumor progression from androgen-dependent to androgen-independent status, the two drugs combined had additive growth-inhibiting activity compared with either drug alone.

Statins for the Treatment of Sepsis 2/20/2008

1 Approximately 750,000 patients develop sepsis each year.

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