Bivalent mRNA Vaccine Shows Superior Antibody Response
Moderna recently announced clinical data on its bivalent Omicron–containing booster, mRNA-1273.214. The data indicated that 90 days after administration as a fourth booster dose in previously vaccinated and boosted participants, a 50-mcg booster dose of mRNA-1273.214 produced a superior neutralizing antibody response against Omicron BA.1 when compared with a 50-mcg booster dose of mRNA-1273 in all participants, regardless of prior infection. Read more.
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Positive Data From Trial of Omicron BA.4/BA.5–Adapted Bivalent Booster Pfizer and BioNTech announced early data from a phase II/III clinical trial assessing the safety, tolerability, and immunogenicity of the companies' Omicron BA.4/BA.5–adapted bivalent COVID-19 vaccine (Pfizer-BioNTech COVID-19 Vaccine, Bivalent [original and Omicron BA.4/BA.5]). A 30-mcg booster dose of the Omicron BA.4/BA.5–adapted bivalent vaccine demonstrated a substantial increase in the Omicron BA.4/BA.5 neutralizing antibody response. Read more.
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