Novel Mechanism Discovered for Anaphylaxis Cases During Surgery
The use of certain drugs during surgery can result in anaphylactic shock, and the exacerbated allergic reaction is explained in 80% or more of those cases by the presence of antidrug antibodies of the immunoglobulin E (IgE) class. The cause has been a mystery, however, in the 10% to 20% of cases where evidence for the involvement of antidrug IgE is lacking, according to a report in Science Translational Medicine. Read more.

Pediatric Critical Anaphylaxis Fatal for 1% of Patients
Anaphylaxis—a rapid-onset, multisystem, and potentially fatal hypersensitivity reaction—doesn’t happen often, but it can have severe—or even fatal—effects in children. A new study sought to determine the prevalence, incidence, and mortality of pediatric anaphylaxis. The report in the Journal of Allergy and Clinical Immunology: In Practice focused on pediatric anaphylaxis admissions with a comprehensive analysis of identified triggers, clinical and demographic information, and death probability.
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