June 13, 2019

ASCO Updates Adjuvant Endocrine Therapy Guidelines for Postmenopausal Women
There are currently three FDA-approved aromatase inhibitors indicated for adjuvant treatment of breast cancer (BC) in postmenopausal women: letrozole, anastrozole, and exemestane. The American Society of Clinical Oncology recently updated its clinical practice guidelines on adjuvant endocrine therapy for postmenopausal women with hormone receptor–positive BC. Read more.

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Effect of Chemo Dose Among Early Breast Cancer Patients
Standard combination chemotherapy reduces mortality by about one-third in patients with early breast cancer. The optimal dosage and timing of these agents, however, is not known, and it has been hypothesized that dose-dense regimens may enhance tumor-cell kill rates, decrease tumor regrowth, and improve the chances of cure. Read more.

Drug Interactions Associated
With CDK 4/6 Inhibitors

CDK 4/6 inhibitors are a new class of agents indicated for the treatment of hormone receptor–positive and human epidermal growth factor receptor–negative breast cancer. A recent paper published in Cancer Treatment Review examined the propensity for these drugs to be involved in drug interactions, as well as their significance. Read more.

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