While positive outcomes with drugs and treatments require prompt intervention, ideally at the first sign of distress, about one-third of women do not experience chest pain when having a heart attack.
In older age groups, men are affected more often and the disease is often misdiagnosed. Triggers include medications such as antibiotics, beta-blockers, and statins.
Among the most frequently prescribed medications, PPIs are associated with an increased risk of fracture, Clostridium difficile infection, community-acquired pneumonia, and vitamin and mineral deficiencies.
A prior history of anxiety, depression, and physical and psychological trauma is significantly predictive of onset of chronic pain in later life. The risk of central sensitization should not be underestimated.
Beta-blockade is one of the toxic systemic effects of ophthalmic timolol found to be stronger and longer- lasting in the elderly.
In the elderly, pharmacodynamic changes can potentially decrease efficacy and increase toxicity of cytotoxic treatments.
Use of corticosteroids in the treatment of respiratory diseases and other common conditions in older adults can cause disturbances of mood, cognition, sleep, behavior, and even delirium or psychosis.
Risk factors for developing an autoimmune disease include age and gender. PMR affects older adults almost exclusively, and women and people of Northern European and Scandinavian descent are at higher risk.
A variety of medications can affect sperm count and quality, and age significantly increases the rate of genetic mutations transmitted via sperm.