U.S. Pharmacist Hypothyroidism Update
December 2018

Exploring Possible Link Between Hypothyroidism and Diabetes
The most common endocrine diseases are thyroid disease and diabetes mellitus, and thyroid hormone is known to regulate insulin sensitivity and glucose homeostasis. A recent Harvard study suggests that low or low-normal thyroid function is associated with increased risk of diabetes, and the researchers say their findings can be used as a baseline for further studies as well as to provide new insights on this relationship. Here are more details.


No Benefit to Treating Subclinical Hypothyroidism in Older Patients
According to reports, 8% to 18% of adults over age 65 years have subclinical hypothyroidism, characterized by high thyroid-stimulating hormone levels with normal T4 levels. The use of thyroid hormone replacement to treat subclinical hypothyroidism in older patients, however, is controversial, and a recent study in The New England Journal of Medicine found no benefit to levothyroxine in relieving the symptoms of hypothyroidism in this age group. Read more.

Should Pregnant Women Receive Thyroid Hormone Replacement?
Thyroid-stimulating hormone levels generally decline in pregnant women compared with nonpregnant females, but it has not been established whether thyroid replacement is beneficial in this patient population. Understanding the benefits and harms of treatment in these patients is very important since subclinical hypothyroidism occurs in roughly 15% of pregnancies in the United States, and a new study in BMJ sheds light on this little-researched topic. Read more.

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