Perioperative Dextrose Infusion Relieves Laparoscopic Surgery–Related Nausea, Vomiting
Postoperative nausea and vomiting (PONV) are common following laparoscopic surgery and are thought to be caused by stimulation of mechanoreceptors in the intestine secondary to abdominal gas insufflation. Investigators conducted a meta-analysis to assess the effects of perioperative dextrose infusion on preventing PONV in patients undergoing laparoscopic surgery. Learn about the use of perioperative glucose infusion as another therapeutic intervention to help manage PONV.

No Benefit Associated With TDM of Piperacillin/Tazobactam in Sepsis
Sepsis or septic shock are associated with significant mortality. Appropriate antibiotic therapy is essential as failure to meet bactericidal or bacteriostatic pharmacokinetic and pharmacodynamic targets has been associated with poorer outcomes. A recent study provides another tool for pharmacists to assist in allocating scarce resources since the use of therapeutic drug monitoring (TDM) may not be appropriate under all circumstances. Read more.

Preventing Contrast-Induced Nephrotoxicity in Patients With Impaired Renal Function
Contrast-induced nephrotoxicity occurs in 1% to over 50% of patients undergoing coronary angiographic procedures and is associated with a fourfold increased risk of 90-day death, need for dialysis, or persistent kidney injury. A recent study provides information for pharmacists by demonstrating the value of matched hydration and forced diuresis over standard hydration protocols in patients requiring contrast media for coronary procedures. Read more.