August 2022

Temperature Excursion Requirements for Refrigerated Medications
Refrigeration of medications is often required to maintain medication stability and increase a drug's shelf life. Any break in cold-chain storage can potentially affect the safety and efficacy of a medication that requires special temperature requirements. With the increased availability of therapeutic protein products, such as biologic agents and vaccines, the need for cold storage has increased. Read more.


Reactions Associated With Aminoglycosides, Clindamycin, Linezolid, and Metronidazole
Although antibiotics are life-saving medications, there are times when they can place a patient in a life-threatening situation due to the occurrence of hypersensitivity reactions. Immediate hypersensitivity reactions involve immunoglobulin E–mediated release of histamine and other mediators from mast cells or basophils. This type of reaction is exemplified by anaphylaxis, allergic rhinoconjunctivitis, or urticaria. Learn more about these hypersensitivity reactions.

Obesity and Administration, Absorption of SC and IM Medications
The SC and IM routes of administration are preferred over the IV route when it is desirous to slow the onset of the effect of a medication or prolong its duration of action, or when a patient is combative and it is too problematic to insert an IV line. Obesity can alter the rate and absorption of medications, especially those that are lipophilic. Read more.

Connect With U.S. Pharmacist
Facebook Twitter USP Google AppUSP Itunes App