January 2023

Ultra-Rapid Versus Rapid-Acting Insulin in Infusion Pumps
Insulin pumps generally use rapid-acting insulin (RAI) formulations; however, a drawback of RAI formulations is that they do not achieve adequate postprandial glucose control. To optimize glycemic control, attention has focused on the use of fast-acting insulin aspart and ultra-rapid lispro, which naturally mimic endogenous insulin secretion, resulting in more efficient glucose lowering and time in range. Read more.


Can Cefazolin Be Used to Treat CNS Infections?
Infections of the central nervous system (CNS), which include meningitis, encephalitis, ventriculitis, and brain abscesses, are difficult to treat. Success of anti-infective therapy is dependent on a drug’s physiochemical penetrative properties (i.e., cerebrospinal or parenchymal concentrations relative to plasma concentrations) and on drug concentrations achievable in the CNS. Learn more about a study of cefazolin to treat CNS infections.

Bloodstream Infections From Pediatric IV Fat Emulsion Preparations
The administration of parenteral nutrition via central venous catheters is a major source of catheter-related bloodstream infections (CR-BSIs). Efforts are continuously being made to identify risk factors that increase this potentially devastating consequence of hyperalimentation so that mitigation strategies may be implemented. A recent study analyzed CR-BSI rates in pediatric patients receiving IV fat emulsions. Read more.

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