Continuous Versus Bolus IV Loop Diuretics in Heart Failure
A recent study indicated that IV loop diuretic therapy provided the most rapid and effective relief for signs and symptoms of congestion leading to hospitalization for heart failure. Additionally, no changes in patients’ global assessment of symptoms or in renal function had been observed when administered by continuous infusion, by bolus injection, at a high dose, or at a low dose. Read more.

Techniques to Determine Incompatibility of Y-Site Pediatric Medications
The administration of parenteral medications poses a challenge in the pediatric population as compatibility data are often limited since these drugs are studied and administered in different concentrations than are used in adults. Incompatible medications may form particles that are subvisible can cause microcirculatory impairment, pulmonary dysfunction, cardiovascular arrest, multiorgan failure, kidney injury, myocardial damage, and negative immune-modulating effects. Read more.

IV Antihypertensives in Hospital-Associated Acute Severe Hypertension
Guidelines on the management of hypertension and hypertensive emergencies warn that excessive reduction of blood pressure can lead to renal, cerebral, or coronary ischemia and should be avoided; however, clinicians often treat acute severe hypertension, which occurs in non-ICU patients, with IV antihypertensives even though there is no substantive evidence that hypotensive agents improve outcomes in the absence of acute target organ damage. Read more.