U.S. Pharmacist eNewsletter
May 2023

Neurocognitive Impairment and Role in Psychiatric Hospitalizations
Previous research has established that in those with affective disorders, neurocognitive impairments are correlated with poor clinical and employment outcomes. In a recent publication, researchers conducted the largest longitudinal study to examine neurocognitive impairments’ role in psychiatric hospitalizations and sociodemographic conditions. The authors found that clinically significant impairment in verbal memory was correlated with a greater risk of impending hospitalization. Read more.

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Factors Predicting Patient Response to MDD Treatment 
Emory University researchers provided details about two long-term, National Institutes of Health–funded studies in which scientists sought to obtain a better understanding into factors that could aid clinicians in predicting how well three first-line therapies may work for adults diagnosed with major depressive disorder (MDD). Read more.

Correlation Between MDD, Disruptions in Gut Microbiome
In a recent publication in the Journal of the American Medical Association Psychiatry, researchers conducted a cohort study that sought to find the metabolic signatures of major depressive disorder (MDD), use Mendelian randomization to clarify the direction of correlations, and to assess the interaction between the human gut microbiome and metabolome in the pathogenesis of MDD. Read more.


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