U.S. Pharmacist Weekly News Update
August 1, 2019

Diastolic Blood Pressure Independently Results in Adverse CVD Outcomes
Pharmacists may have to revise their view of blood pressure components and how elevated levels affect cardiovascular risk. Find out how a new study determined that elevated diastolic blood pressure also raises the risk of cardiovascular disease (CVD), challenging the assumption that only high systolic blood pressure impacts CVD risk.


Despite FDA Efforts, Too Many
Women on Acne Drugs
Become Pregnant

Pharmacists are well aware of the burden of complying with the FDA’s iPLEDGE program for women taking isotretinoin. Despite that, pregnancies have continued—albeit at a lower level—in women taking the potent teratogen. Here is more information on the trend and what can be done about it.

HIV PrEP Effect on Bone Density Less Than Previously Expected
Public health officials have heavily promoted pre-exposure prophylaxis in some groups as an effective way to reduce the risk of contracting HIV. That’s why past research suggesting the therapy can significantly decrease bone density was so disturbing. Now, a new study says the effects are not as great as previously reported and that alternatives exist for those at high risk of bone density loss.

Tight Glycemic Control
Increases Fracture Risk
in Men With Diabetes

When it comes to hemoglobin A1c, how low is too low? Find out why a study in older men cautions that levels below 6.5% can significantly increase fracture risk, compared with a range of 7.5% to 8.5%, as well as how insulin and metformin affect that risk.

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