US Pharm. 2013;38(2):HS-12-HS-18.
ABSTRACT: Cardiac asthma is a condition secondary to heart failure
that is marked by dyspnea, wheezing, cough, frothy or bloody sputum,
and rales.1 These symptoms usually occur at night and are
more prevalent in the elderly population. Because its symptoms are
similar to those of bronchial asthma, cardiac asthma is often
misdiagnosed. However, an accurate diagnosis is imperative because
treatments for the two conditions differ, and incorrect treatment can
exacerbate cardiac asthma.2 IV furosemide, nitroglycerin, and morphine are used for the acute treatment of cardiac asthma.3 If the patient is hypoxic, supplemental oxygen also may be used.3 Outpatient medication regimens focus on treating heart failure.
In 1833, the physician James Hope coined the term cardiac asthma to describe the inadequate oxygenation of blood and the sensation of wanting breath resulting from it.1,4
Since then, cardiac asthma has been better defined, but there is still
much confusion surrounding its diagnosis. In fact, cardiac asthma is
commonly mistaken for bronchial asthma since both conditions have
similar symptoms and timing.5 However, the primary mechanisms that cause these symptoms are dissimilar.5 By focusing on the subtle differences in symptoms and test results, providers can more easily differentiate the disorders.
Cardiac asthma involves paroxysms of dyspnea (breathlessness) and
wheezing that often occur during the night as a result of congestion in
the lungs secondary to heart failure (HF).4-6 In bronchial
asthma, symptoms are due to an inflammatory process, rather than a
cardiac process. It is important to correctly identify the etiology of
the patient’s symptoms because treatment differs for these disorders,
and incorrect treatment of cardiac asthma may exacerbate the condition.
Since cardiac asthma and bronchial asthma have differing etiologies,
it is pertinent to discuss epidemiological differences because the
disease processes dictate the populations most affected. It makes sense
that HF would be more prevalent in the elderly, given the disease
progression. The American Heart Association’s 2011 update reported that
HF has an incidence of 10 per 1,000 population in people older than 65
years, and the incidence of new HF events is at least 15 per 1,000.7
The incidence of new HF events can exceed 65 per 1,000 population in
people older than 85 years, supporting a direct relationship between HF
and age.7 Prevalence rates of HF in patients aged 20 to 30
years and those aged 80 years and older (0.3% and 11.5%, respectively)
also support this relationship.7
The incidence and prevalence of cardiac asthma are unclear, owing to
insufficient data from published studies. In a 2007 study, the incidence
of cardiac asthma in elderly patients was 35%, versus the 10% to 15%
incidence seen in younger patients in earlier studies.8
Trends noted in the cardiac asthma group (in the 2007 study) were
increased use of tobacco products and diagnosis of chronic obstructive
pulmonary disease.8 One factor not considered in this study
was whether the wheezing was cardiac or pulmonary in origin, a
distinction that could affect incidence results.8
Asthma is more prevalent in children than in adults. According to the
2009 CDC National Health Statistics report, 9.6% of children and 7.7%
of adults had asthma.9 Boys were found to have a higher prevalence than girls, whereas in adulthood the opposite was true.9 In patients aged 85 years, asthma prevalence was approximately 5% in both men and women.9
The epidemiological differences between cardiac asthma and bronchial
asthma reveal that cardiac asthma is more likely to occur in an older
adult population, whereas bronchial asthma is more likely in children.
Nevertheless, more research is necessary to clarify the incidence and
prevalence of cardiac asthma.
In congestive heart failure (CHF), the heart’s inability to pump
blood out of the left ventricle results in excess fluid in the pulmonary
circulation.10 Pulmonary congestion is the consequence of
fluid being pushed into the alveolar lumen. Cardiac asthma may be
associated with bronchiolar pathology, rather than simply the
accumulation of alveolar fluid.
Not only does the presence of fluid in the lungs make breathing
difficult, it can cause asthmalike symptoms as well. The wheezing
experienced by CHF patients may be due to a narrowing or obstruction of
the bronchioles rather than simply to pulmonary congestion. Various
studies have identified bronchial hyperreactivity as the mechanism
behind cardiac asthma.11-13 Patients in these studies inhaled
either acetylcholine or methacholine (cholinergic agonists). Compared
with patients without cardiac asthma symptoms, those with symptoms
demonstrated greater airway narrowing in response to the inhaled drug.
The mechanism by which this narrowing occurs is not fully understood.
Another study suggested that downregulation of beta2 receptors resulting from excessive adrenergic stimulation might cause bronchoconstriction in HF patients.14 Either mechanism is detrimental and undesirable in patients already experiencing pulmonary congestion.
Cardiac asthma may be better attributed to bronchial anatomy. The
bronchial blood supply involves a separate vascular system from that
which supplies the alveoli. Similar to the mechanism of fluid buildup in
the alveoli, the blood supply to the bronchioles may exhibit fluid
buildup. Two hypotheses exist regarding the pathophysiology behind this:
theory A and theory B (FIGURE 1).10 Theory A
hypothesizes that an increase in blood flow to the bronchial circulation
may produce edema in the interstitial space, thereby squeezing the
bronchiolar lumen.10 Conversely, theory B posits that certain
pathological changes in HF, including pulmonary edema (PE), may compete
for interthoracic space, compressing the entire airway structure and
the bronchiole wall.10
The pathologic cause of cardiac asthma is not definitively explained.
Reflex bronchoconstriction involving the vagus nerve has been
suggested. Increased pulmonary vascular pressure may stimulate afferent
nerve endings, causing reflex narrowing of large and small airways.15
Reflex bronchoconstriction, in addition to edema and hyperreactivity,
can exponentially reduce breathing capability in CHF patients. The
pathophysiology of cardiac asthma may incorporate a combination of
mechanisms, creating a number of treatment challenges. The absence of
inflammation is the major difference between cardiac asthma and
bronchial asthma, even though the symptoms are similar.
Clinical Presentation and Differential Diagnosis
As noted earlier, cardiac asthma involves symptoms of airflow obstruction that are due to HF.16
In most cases, the clinical presentation includes severe dyspnea,
cough, frothy or watery sputum, and rales, but the most significant
symptom indicative of cardiac asthma is wheezing.4,6 These symptoms are more prevalent in elderly patients.4
Cardiac asthma often is characterized by abrupt waking from sleep caused by sudden, severe episodes of dyspnea.4
In a typical attack, the symptoms generally subside after the patient
sits upright for 20 to 30 minutes, after which he or she may be able to
return to bed without needing medication.6 In severe cases,
the patient may experience recurrent episodes in a single night and have
cyanosis (blue or purple discoloration of the skin), cold sweats,
blood-tinged sputum, and fluid buildup in the lungs.4,6 Cardiac asthma is difficult to diagnose because its symptoms are similar to those of bronchial asthma. TABLE 1 compares symptoms and diagnosing strategies for asthma, HF, and cardiac asthma.6,16-22
There are a few subtle differences between cardiac asthma and true
asthma. Asthma often is triggered by allergens or some other
precipitating factor (TABLE 1), and symptoms tend to worsen at
night; cardiac asthma attacks occur almost exclusively at night when the
patient is lying in bed.4 Because of preexisting heart
disease, cardiac asthma patients usually have an enlarged heart
(cardiomegaly) that can be seen upon chest x-ray, whereas asthma
patients have a normal-sized heart.4 Severe cardiac asthma typically involves PE, which causes dyspnea, coughing, and wheezing.4 Unlike asthma, however, cardiac asthma responds poorly to bronchodilators.16
Another distinction between the two disorders is circulation time
(how long it takes for blood to flow from one part of the body to
another).16 In the past, circulation time typically was
measured by injecting sodium dehydrocholate into an arm vein and
measuring how long it took to produce a bitter taste on the tongue
(arm-to-tongue circulation).23 However, this test’s
unreliability caused it to be replaced by other techniques, including
radionuclide angiocardiography, CT, and MRI.23 Circulation
time is believed to be prolonged in HF patients; therefore, measurement
may provide crucial information for differentiating between pulmonary
and cardiac disorders.16,23
Since cardiac asthma stems from a heart problem, it can be difficult
to distinguish its symptoms from those of HF. The three cardinal
symptoms of HF are dyspnea, fatigue, and fluid retention; the presence
of wheezing is diagnostic of cardiac asthma.18 Chronic HF often is associated with decreased forced expiratory volume in 1 second (FEV1); however, in one study, cardiac asthma patients (defined as having CHF and wheezing) exhibited lower FEV1 values than patients with CHF alone.8,16
Chest x-ray is useful for confirming the presence of pulmonary
congestion as well as for identifying cardiomegaly, which also indicates
a heart disorder.4,15 Cardiomegaly often occurs in cardiac asthma patients, but not to the same degree as in strictly HF patients.8
Physical examination and lung auscultation may reveal rales, which are
attributable to PE, but the best way to diagnose HF is to obtain a
two-dimensional echocardiogram with Doppler, which can identify
structural abnormalities and reduced ejection fraction (EF).4,8,19
Currently, no well-defined treatment plans exist for cardiac asthma
in the acute or chronic setting. Discussions of cardiac asthma
management target the pathophysiology of the underlying condition (i.e.,
PE and HF). The use and efficacy of bronchodilators such as albuterol
and ipratropium, which are used to relieve symptoms of bronchial asthma,
have not been established in cardiac asthma.8
Traditional medications used in the acute treatment of cardiac asthma include furosemide, morphine, and nitrates (TABLE 2).3,4,17 Supplemental oxygen, noninvasive ventilation (NIV), and proper positioning of the patient also are important.3
Each treatment has a unique benefit and may work synergistically with
other treatments. Because patients presenting with an acute episode of
cardiac asthma usually are hypoxic, the initial use of oxygen and/or NIV
is recommended and has been shown to decrease mortality.24,25
If the patient shows no signs of hypoxia, oxygen and NIV are not
recommended. As mentioned previously, a patient who awakens at night
with dyspnea may alleviate symptoms by remaining awake for 20 to 30
minutes. Proper positioning, in which the patient stands erect or sits
upright with feet hanging off the side of the bed, will result in
decreased venous return.26,27 The amount of blood to the
bronchioles is thereby lessened, interstitial-space edema is reduced,
and the squeezing effect of the bronchiolar lumen described in theory A
Patients experiencing an acute cardiac asthma episode likely will
require fluid removal. In such cases, gradual diuresis using a loop
diuretic is warranted. Furosemide, which acts at the ascending portion
of the loop of Henle and at the distal tubule, inhibits the reabsorption
of sodium and chloride and causes diuresis.25-27 This
improves symptoms by reducing preload in the heart. Symptomatic
improvement in patients with pulmonary congestion is seen with an
initial recommended furosemide dosage of 40 mg IV.25-27 The
dose may be increased based on clinical response but must remain gradual
to avoid hypotension, electrolyte disturbances, gout exacerbations,
hearing loss (reversible), and worsening renal function.24-27
Some patients may exhibit persistent pulmonary congestion despite
aggressive diuresis. In these instances, an IV nitrate (e.g.,
nitroglycerin) may be used adjunctively in both hypertensive and
normotensive patients. Acting as a venodilator, nitroglycerin will
lessen the pressure in the left ventricle, thereby reducing pulmonary
congestion.25,26,28 Nitroglycerin should be started at a
dosage of 5 mcg/min; it may be titrated to 200 mcg/min. Nitroglycerin
dosing beyond 200 mcg/min is not recommended, and the patient requiring
it should be considered a nonresponder.25,26,28 Some side effects associated with nitroglycerin use are hypotension, headache, and abdominal pain.
IV morphine ameliorates symptoms in patients with pulmonary congestion.4,24
Morphine used in the setting of cardiac asthma enables easier breathing
and reduces a patient’s anxiety level during the episode.4,25,26,29 The mechanism by which easier breathing occurs is believed to involve venodilation and reduction in preload.4,25,26,29 The morphine dosage commonly used is 1 to 3 mg IV every 5 minutes until relief occurs without inducing respiratory depression.24-26,29
Once the acute cardiac asthma episode is resolved, HF therapy should
be initiated or optimized to prevent future occurrences. The use of ACE
inhibitors and beta-blockers in HF patients is recommended to decrease
morbidity and mortality rates.24,25 The continuance of
diuretics postepisode will help maintain a normal volume status in this
patient population and prevent future cardiac asthma occurrences.
Digoxin, although not shown to reduce mortality, may be used to improve
congestive symptoms in patients with HF. Additional information about
chronic HF management, including anticoagulation, amiodarone use,
alternative treatments, dosing, and so on, may be found in current HF
The incidence of cardiac asthma will likely increase as knowledge
about diagnosis and treatment improves. Current management of cardiac
asthma focuses on controlling the underlying HF and PE.5
Recognition of cardiac asthma and recommendations concerning appropriate
treatment can greatly reduce disease occurrence and significantly
improve the patient’s quality of life.4,7 Pharmacists can
make a significant impact on the diagnosis and progression of this
little-known disease. Counseling patients who are at risk for cardiac
asthma and who present with related issues will enhance proper
diagnosis. Pharmacists familiar with treatment options and optimization
of therapy for concomitant diseases can better manage their patients’
symptoms, improve quality of life, and help slow the progression of this
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