US Pharm. 2014;39(3):49-50.
The role of the so-called “obesity
hormone” leptin and hormones used for birth control in the development
of multiple sclerosis (MS) is examined in two new studies that will be
presented at the American Academy of Neurology’s 66th Annual Meeting in
Philadelphia. For the obesity study, BMI was calculated for 210 people
with MS and 210 people of the same age and sex who did not have MS at
ages 15 and 20 and at the time of the study. People who are obese at
age 20 are twice as likely to later develop MS, the study found, as
people who are not obese. The study also found that people with higher
BMI levels had higher levels of leptin, a hormone made by fat tissue
that regulates weight, appetite, and immune response.
“Leptin promotes inflammatory responses
in the body, which could potentially explain the link between obesity
and MS,” said study author Jorge Correale, MD, of the Raúl Carrera
Institute for Neurological Research in Buenos Aires, Argentina.