December 23, 2022

Genetic Mutations Suggest Higher PML Risks

With more than three dozen prescription drugs creating risk for an aggressive demyelinating disorder, progressive multifocal leukoencephalopathy (PML), the discovery of the demyelinating disorder’s link with four genetic mutations will potentially improve safety. Find out why the authors say their discovery will allow better screening, which is especially important as the use of the drugs increases.


Paxlovid Reduces Risk of Death, Hospitalization in COVID-Vaccinated Patients

A new study raises the question of whether even broader use of Paxlovid might be advisable in COVID-19 patients. The researchers pointed out that emerging data involving the initial Omicron variants show a potential benefit of nirmatrelvir plus ritonavir regardless of vaccination status, adding that only a small proportion of the eligible patient populations appear to have been treated. Read more.

Highest Flu, Other Respiratory Virus Rates in Over a Decade

As of early December, this year’s influenza season is shaping up as the worst in at least a decade, with high rates of hospitalization and even death. Complicating matters are high levels of RSV and mounting COVID-19 cases during the holiday season, according to the CDC, which is strongly urging both flu and COVID vaccination. Read more.


Boosters Important to Maintain Children’s Protection Against COVID-19

Two doses of the Pfizer-BioNTech COVID-19 vaccine provided limited protection against Omicron infection in children aged 5 to 11 years, according to a new study published in the Journal of the American Medical Association. Because effectiveness waned after a few months, the authors emphasized the importance of a booster to restore and maintain protection for at least 3 more months. Read more.

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