February 26, 2020

Guideline-Preferred Diuretic, Chlorthalidone, Causes More Serious Side Effects

Although current clinical guidelines recommend chlorthalidone over hydrochlorothiazide when thiazide and thiazide-like diuretics are called for, a new study cautions pharmacists and other healthcare professionals about the significantly greater risk of hypokalemia and other electrolyte imbalances and kidney problems in patients using the preferred drug. Here are more details.


Statin-Metformin Combo Lowers Mortality Rates
in High-Risk Prostate Cancer

In the search for treatments to extend life in men with high-risk prostate cancer, a new study reports that some effective medications are found in millions of patients’ medicine cabinets. Find out how researchers determined that statins, alone or with metformin, can increase survival in men with hard-to-treat prostate cancer.

New Study Helps Quantify Methotrexate Side Effects

Although methotrexate has been in use for 40 years and is the first-line therapy for rheumatoid arthritis, relatively little information is available on the drug’s side effects. Find out how a new study sought to remedy that lack of knowledge and what side-effect risks were detailed.


Long-Term Migraine Prophylaxis Not Effective in Pediatric Patients

A systematic review and meta-analysis sought to determine the most effective ways to prevent migraine occurrence in pediatric patients. While researchers found that propranolol and topiramate were significantly more effective than placebo in the short term, they found no good options for long-term prophylaxis. Here are more details.

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