US Pharm. 2016;41(9):12.
Boston, MA—Contrary to earlier reports, asthma in young children is not worsened by acetaminophen, according to a multicenter, randomized, prospective trial conducted by Boston Children’s Hospital. Families of 300 children aged 1 to 5 years with mild, persistent asthma were randomized to give the children either acetaminophen or ibuprofen as indicated for pain or fever over 48 weeks. Both groups received the same asthma-control therapies, and medication adherence was closely monitored. The trial was completed by 75% of patients. The amounts of acetaminophen and ibuprofen used for pain or fever were similar between groups (median 5.5 doses). There were no between-group differences in asthma exacerbation or control, and researchers concluded that acetaminophen does not aggravate asthma in young children on controller therapy for mild asthma.To comment on this article, contact firstname.lastname@example.org.