US Pharm. 2006;11:20-28.

Agitation (increased verbal and/or motor activity as well as restlessness, anxiety, tension, and fear) and aggression (self-assertive verbal or physical behavior arising from innate drives and/or a response to frustration that may manifest by cursing/threats and/or destructive and attacking behavior toward objects or people) are symptoms commonly present in patients with central nervous system (CNS) disorders.

For example, patients with dementia present with cognitive impairment as well as behavioral and psychological symptoms, including agitation, aggression, irritability, delusions, sleep disorders, anxiety, and phobias.1 The most common form of dementia, Alzheimer